Survival After Fertility-Preserving Hormonal Therapy vs Hysterectomy for Early-Stage Endometrial Cancer
This study found that the use of fertility-preserving hormonal therapy among reproductive age patients with early-stage endometrial cancer has increased over time. While overall survival in patients with hormonal therapy is shorter than with hysterectomy, survival for patients younger than 40 years of age is comparable after primary treatment with fertility-preserving hormonal therapy or hysterectomy.
Authors
- Yukio Suzuki (ORCID: https://orcid.org/0000-0002-2178-6562)
- Chung Yin Kong (ORCID: https://orcid.org/0000-0001-6431-7830)
- Yongmei Huang (ORCID: https://orcid.org/0000-0001-6248-2832)
- Haruya Saji
- Xiao Xu (ORCID: https://orcid.org/0000-0001-6519-1731)
- Elena B. Elkin (ORCID: https://orcid.org/0000-0001-8833-4213)
- Stephanie V. Blank (ORCID: https://orcid.org/0000-0003-0605-6753)
- Laura Jean Havrilesky (ORCID: https://orcid.org/0000-0002-4259-5992)
- Etsuko Miyagi (ORCID: https://orcid.org/0000-0002-5492-0844)
- Evan R. Myers (ORCID: https://orcid.org/0000-0002-9053-9864)
- Dawn L. Hershman (ORCID: https://orcid.org/0000-0001-8807-153X)
- Jason D Wright
- Jennifer S. Ferris (ORCID: https://orcid.org/0000-0003-2901-9349)
Institutions
- Duke University (US)
- Kanagawa Prefectural Hospital Organization (JP)
- Duke Medical Center (US)
- Kanagawa Cancer Center
- Columbia University (US)
- Yokohama City University (JP)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1001/jamaoncol.2025.2761
- Citations
- 7
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 14.40