Evaluation of a Novel Patient-Centered Methadone Restart Protocol
In this cohort study of individuals with opioid use disorder restarting methadone after a gap in treatment, an individualized methadone restart protocol that considered interim opioid tolerance was associated with higher restart doses without compromising safety or treatment retention. Further research is needed to evaluate if this approach improves treatment outcomes.
Authors
- Hermione Hurley (ORCID: https://orcid.org/0000-0001-5183-2390)
- Hannan M. Braun (ORCID: https://orcid.org/0000-0003-0864-4807)
- Joshua Blum (ORCID: https://orcid.org/0009-0001-5910-3034)
- Alia Al‐Tayyib (ORCID: https://orcid.org/0000-0002-5909-6719)
- Paul J. Christine (ORCID: https://orcid.org/0000-0003-1707-0761)
- Alexandra R. Tillman (ORCID: https://orcid.org/0000-0001-5699-6466)
- Martin Hinrichs
Institutions
- Denver Health Medical Center (US)
- Denver Public Health (US)
- Health and Hospital Corporation (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.29393
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Center for Research Resources
- Colorado Clinical and Translational Sciences Institute