Established Cancer Predisposition Genes in Single and Multiple Cancer Diagnoses
This genetic association study demonstrates several established associations between cancer predisposition genes and cancer diagnoses in an unselected population-based study. These results also demonstrate that RPVs in cancer predisposition genes are associated with multiple primary cancer diagnoses, suggesting that multigene panel testing may be warranted in these individuals.
Authors
- Jennifer Beebe‐Dimmer (ORCID: https://orcid.org/0000-0002-4320-739X)
- Kathleen A. Cooney (ORCID: https://orcid.org/0000-0003-3831-6943)
- Zhuqing Shi (ORCID: https://orcid.org/0000-0001-6321-950X)
- S. Lilly Zheng (ORCID: https://orcid.org/0009-0005-3514-2468)
- Jeffrey Shevach (ORCID: https://orcid.org/0000-0002-3982-781X)
- Jianfeng Xu (ORCID: https://orcid.org/0000-0001-5592-3265)
- Nathan Snyder (ORCID: https://orcid.org/0000-0001-9204-8420)
- Jun Wei (ORCID: https://orcid.org/0000-0001-9950-0467)
- Huy Tran (ORCID: https://orcid.org/0009-0006-1648-3280)
Institutions
- NorthShore University HealthSystem (US)
- Duke University (US)
- Wayne State University (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Duke Medical Center (US)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1001/jamaoncol.2025.2879
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.81