Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism
Silybin effectively ameliorates post-myocardial infarction heart failure through the HIF-1α-mediated regulation of glycolysis, leading to improved myocardial energy metabolism and enhanced cardiac function.
Authors
- Mengyuan Wang
- Jinhong Chen (ORCID: https://orcid.org/0000-0003-0952-9990)
- Jiaqi Zhao (ORCID: https://orcid.org/0000-0003-1212-9525)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-5552-2354)
- Tianyu Wang (ORCID: https://orcid.org/0000-0002-7747-2685)
- Junyan Wang (ORCID: https://orcid.org/0000-0002-2048-2225)
- Zhongzheng Zhang
- Haowen Zhuang (ORCID: https://orcid.org/0009-0002-2484-4235)
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3390/nu17172800
- Citations
- 2
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China