Predictors and Outcomes of Non-Small Cell Lung Carcinoma Patients Following Severe Immune Checkpoint Inhibitor Toxicity: A Real-World UK Multi-Centre Study
In ≥Grade 3 irAEs patients managed with corticosteroids, lower baseline NLR, longer ICI use, response to ICI after 1st irAE, and a ≤60 mg corticosteroid dose had promising outcomes.
Authors
- Michael Skwarski
- Nicholas Anthony Coupe (ORCID: https://orcid.org/0000-0002-5729-317X)
- M. Förster (ORCID: https://orcid.org/0000-0001-7639-290X)
- Siow Ming Lee (ORCID: https://orcid.org/0000-0002-1741-6235)
- Spyridon Gennatas (ORCID: https://orcid.org/0000-0002-5635-7696)
- Sarah Benafif (ORCID: https://orcid.org/0000-0003-1407-1697)
- Eleni Karapanagiotou
- James Spicer (ORCID: https://orcid.org/0000-0003-3732-8491)
- Dionysis Papadatos-Pastos
- Alexandros Georgiou (ORCID: https://orcid.org/0000-0001-7500-9251)
- Eleni Josephides
- Umair Mahmood (ORCID: https://orcid.org/0000-0002-2926-3205)
- Meenali Chitnis (ORCID: https://orcid.org/0009-0006-5414-7907)
- Mariam Jamal-Hanjani
- Charles Swanton
- Tanya Ahmad
- Sharmistha Ghosh
Institutions
- Guy's Hospital (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- The Francis Crick Institute (GB)
- Cancer Research UK (GB)
- London Cancer (GB)
- Oxford University Hospitals NHS Trust (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- King's College Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3390/cancers17172819
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14