Aberrant white–gray matter functional coupling in rhegmatogenous retinal detachment: evidence from resting-state functional MRI and machine learning

These findings reveal aberrant spontaneous low-frequency oscillatory activity and enhanced white matter-gray matter coupling in patients with RRD, reflecting cross-tissue functional reorganization beyond the retina. Notably, the elevated fALFF signal in the left ALIC demonstrates strong potential as a neuroimaging biomarker. This study underscores the value of white matter functional metrics in characterizing central nervous system alterations in RRD and offers novel insights into its neurobiological underpinnings.