Haptoglobin phenotypes and structural variants associate with post-exertional malaise and cognitive dysfunction in myalgic encephalomyelitis
These findings suggest that Hp phenotype and proteoform structure modulate the physiological response to post-exertion in ME, offering insight into the molecular basis of PEM and its clinical heterogeneity. Hp may serve as a translational biomarker for patient stratification and a potential therapeutic target to mitigate oxidative stress and cognitive dysfunction in ME.
Authors
- Iurie Caraus
- Wenzhong Xiao (ORCID: https://orcid.org/0000-0003-4944-6380)
- Anita Franco
- Christian Godbout
- Bita Rostami-Afshari
- Wesam Elremaly (ORCID: https://orcid.org/0000-0002-3577-3551)
- Jonas Bergquist (ORCID: https://orcid.org/0000-0002-4597-041X)
- Atefeh Moezzi
- Corinne Leveau
- Anna Widgren
- Peng Li (ORCID: https://orcid.org/0000-0003-2030-1807)
- Alain Moreau (ORCID: https://orcid.org/0000-0002-4827-9472)
- Oleg Nepotchatykh
- Anastasiya Ushenkina
Institutions
- Uppsala University (SE)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Massachusetts General Hospital (US)
- RF Laboratories (United States) (US)
- Université de Montréal (CA)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s12967-025-07006-z
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Open Medicine Foundation
- Eesti Teadusagentuur
- Uppsala Universitet
- Canadian Institutes of Health Research
- Estonian Research Competency Council
- Institute of Musculoskeletal Health and Arthritis