Identification of 2 <i>H</i> ‐chromene Based Novel Benzamides as Potential Free‐Radical Scavenging Agents and α‐Glucosidase Inhibitors

Abstract Azlactones ( 3a‐d ) were reacted with different amines at room temperature to create a total of forty 2 H ‐chromene based benzamides ( 4a‐zn ). Azlactones' rings were opened to get the desired compounds and examined for its ability to scavenge free radicals (DPPH, ABTS + ) and inhibit α‐glucosidase. Ten benzamide compounds were shown to be strong ABTS + free radical scavengers, and three benzamide compounds 4p , 4zd , and 4zf were found to be the most effective α‐glucosidase inhibitors. Compound 4zf was shown to be an α‐glucosidase inhibitor and ABTS + free‐radical scavenger. To further illustrate the molecular basis of α‐glucosidase inhibition, molecular docking and simulation studies were performed for potential compounds.