Retinal Vessel Changes in Geographic Atrophy in AMD: Insights From Imaging and Histology
Retinal vascular changes in GA predominantly occur within regions of RPE atrophy. The preservation of perfusion in regions without RPE atrophy suggests that vascular impairment is localized. These findings underscore the importance of regional analysis and histopathologic correlation in understanding vascular remodeling in GA. Future longitudinal OCTA studies are warranted to clarify the temporal progression of these vascular alterations in relation to RPE atrophy.
Authors
- Enrico Borrelli (ORCID: https://orcid.org/0000-0003-2815-5031)
- Giovanni Neri (ORCID: https://orcid.org/0009-0008-7176-9593)
- Michele Reibaldi (ORCID: https://orcid.org/0000-0003-1368-6729)
- Imran Ahmed Bhutto (ORCID: https://orcid.org/0000-0002-3845-8143)
- Chiara Olivieri (ORCID: https://orcid.org/0009-0002-5207-264X)
- D. Scott McLeod
- Malia M. Edwards
- Antonio Fai
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Piedmont Reference Center for Epidemiology and Cancer Prevention (IT)
- University of Turin (IT)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1167/iovs.66.11.69
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00