Celastrol Activates SIRT1/PGC-1α/Nrf2 Axis to Inhibit Oxidative Damage for Subconjunctival Fibrosis Alleviation
This work demonstrated that Cel effectively alleviated subconjunctival fibrosis by inhibiting oxidative damage via activating SIRT1/PGC-1α/Nrf2 signaling pathway, providing a new potential mechanism to clarify Cel as a potential therapeutic drug to inhibit subconjunctival fibrosis.
Authors
- Yang Liu (ORCID: https://orcid.org/0000-0001-8344-6478)
- Yuting Deng (ORCID: https://orcid.org/0000-0002-9512-756X)
- Zhanrong Li (ORCID: https://orcid.org/0009-0002-6779-7766)
- Jingguo Li (ORCID: https://orcid.org/0000-0002-0471-4540)
- Zhihua Guo (ORCID: https://orcid.org/0000-0003-3302-6955)
- Xue Sun (ORCID: https://orcid.org/0000-0003-1264-6733)
- Huayang Feng
- Qingyun Ning
Institutions
- Henan Provincial People's Hospital (CN)
- Henan Provincial Eye Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1167/iovs.66.11.70
- Citations
- 3
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 5.12