PHPT1 acts as an inhibitor in high-altitude pulmonary hypertension via negative TRPV5 signaling regulation
These findings underscore that PHPT1 inhibits PASMC proliferation and migration through TRPV5 signaling, thereby reducing mPAP and improving right ventricular function in HAPH. Therefore, PHPT1 targeting could potentially contribute to the development of novel therapeutic approaches for treating HAPH.
Authors
- Mingxiang Zhu (ORCID: https://orcid.org/0000-0001-6435-8659)
- Kunlun He (ORCID: https://orcid.org/0000-0002-3335-5700)
- Xin Li (ORCID: https://orcid.org/0000-0002-2122-7461)
- Chunlei Liu (ORCID: https://orcid.org/0000-0002-0260-8074)
- Liming Cheng (ORCID: https://orcid.org/0000-0001-6444-5090)
- Guo Ge (ORCID: https://orcid.org/0000-0002-6362-772X)
- Yibing Chen (ORCID: https://orcid.org/0009-0001-6848-2654)
- Yanying Shen (ORCID: https://orcid.org/0000-0001-9195-2207)
- Xiang Xu (ORCID: https://orcid.org/0000-0002-7259-0885)
- Yong-ming Yao (ORCID: https://orcid.org/0000-0002-3564-4012)
- Hanlu Li
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s12967-025-06980-8
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China