<scp>MCPIP1</scp> Controls Hybrid <scp>EMT</scp> and Tumor Stemness via the <scp>IL6</scp> / <scp>JAK2</scp> / <scp>STAT3</scp> Axis in Pancreatic Cancer
MCPIP1 is a key regulator of PC progression, acting as a tumor suppressor by inhibiting the IL6/JAK/STAT3 signaling pathway. The findings suggest that MCPIP1 is a promising therapeutic target with potential implications for the development of new strategies for managing PC.
Authors
- Zihao Zhu (ORCID: https://orcid.org/0000-0002-9687-6327)
- Qiuping Chen (ORCID: https://orcid.org/0000-0001-9132-0912)
- F. Anthony Lai
- Huanzhong Liu (ORCID: https://orcid.org/0000-0003-3095-5249)
- Xiaohui Li (ORCID: https://orcid.org/0000-0002-0624-8811)
- Rui Wang (ORCID: https://orcid.org/0000-0003-3825-3620)
- Shiqi Liu (ORCID: https://orcid.org/0000-0003-1443-2675)
- Min Liu (ORCID: https://orcid.org/0000-0002-6385-8077)
- Yingying Zheng (ORCID: https://orcid.org/0000-0002-5684-6430)
- Xihui Ding
- Zhenhua Ren (ORCID: https://orcid.org/0000-0002-1426-7457)
- Jinyong Xu
Institutions
- Anhui Agricultural University (CN)
- Anhui Medical University (CN)
- Chaohu Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1002/cam4.71179
- Citations
- 1
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China