Nickel-Catalyzed Carbonylative Cyclization of Bromodifluoroacetamides with Arylboronic Acids toward δ-Lactams

A nickel-catalyzed radical cyclization/carbonylation reaction of bromodifluoroacetamides with arylboronic acids has been explored. This strategy allows for the synthesis of δ-lactams bearing both <i>gem</i>-difluoro and carbonyl groups through a sequential single-electron transfer, 6-<i>exo</i>-<i>trig</i> cyclization, and carbonyl insertion process. This method proceeds under mild reaction conditions with good functional group compatibility, enabling the preparation of various structurally diverse δ-lactams that might have further applications in medicinal chemistry.

Authors

Institutions

Publication Details

Journal
Organic Letters
Published
2025-08-28
DOI
https://doi.org/10.1021/acs.orglett.5c03212
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Nickel-Catalyzed Carbonylative Cyclization of Bromodifluoroacetamides with Arylboronic Acids toward δ-Lactams

Xiao‐Feng Wu, Chen-Yang Hou, Yuting Jiang, Xinxin Qi et al.
Organic Letters
Catalytic C–H Functionalization Methods
article

Nickel-Catalyzed Carbonylative Cyclization of Bromodifluoroacetamides with Arylboronic Acids toward δ-Lactams

Xiao‐Feng Wu, Chen-Yang Hou, Yuting Jiang, Xinxin Qi, Hucheng Ma
article en

Abstract

A nickel-catalyzed radical cyclization/carbonylation reaction of bromodifluoroacetamides with arylboronic acids has been explored. This strategy allows for the synthesis of δ-lactams bearing both <i>gem</i>-difluoro and carbonyl groups through a sequential single-electron transfer, 6-<i>exo</i>-<i>trig</i> cyclization, and carbonyl insertion process. This method proceeds under mild reaction conditions with good functional group compatibility, enabling the preparation of various structurally diverse δ-lactams that might have further applications in medicinal chemistry.

Organic LettersVol. 27(36)
Zhejiang Sci-Tech University (CN), Dalian Institute of Chemical Physics (CN), Chinese Academy of Sciences (CN), Leibniz Institute for Catalysis (DE), Ingenierie des Materiaux polymeres (FR), Dalian National Laboratory for Clean Energy (CN), Interface (United Kingdom) (GB)
Dalian Institute of Chemical Physics, National Key Research and Development Program of China
Openalex Percentile: Top 83%
Catalytic C–H Functionalization Methods
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Nickel-Catalyzed Carbonylative Cyclization of Bromodifluoroacetamides with Arylboronic Acids toward δ-Lactams — Xiao‐Feng Wu, Chen-Yang Hou, et al. · Organic Letters (2025) | TGRS Research Map | TGRS