Flavonols as potent inhibitors of tyrosinase & pancreatic lipase: synthesis, docking, MD simulation, DFT, and ADMET
This is the first study reporting pancreatic lipase inhibition by flavonols alongside their tyrosinase inhibitory potential. These flavonols emerge as promising dual-action candidates for developing treatments targeting obesity and hyperpigmentation.
Authors
- Amina Sadiq
- Ayesha Jabeen (ORCID: https://orcid.org/0000-0002-4816-2741)
- Saleh A. Ahmed (ORCID: https://orcid.org/0000-0002-2364-0380)
- Nafeesa Naeem (ORCID: https://orcid.org/0000-0002-6647-9697)
- Munirah M. Al‐Rooqi
- Zobia Noreen (ORCID: https://orcid.org/0000-0002-2452-2730)
- Bushra Shakoor
- Ehsan Ullah Mughal (ORCID: https://orcid.org/0000-0001-9463-9398)
- Reem I. Alsantali (ORCID: https://orcid.org/0000-0001-9183-7620)
- Nusrat Shafiq (ORCID: https://orcid.org/0000-0002-3270-4227)
- Adem Korkmaz (ORCID: https://orcid.org/0000-0002-0345-5794)
- Ercan Bursal (ORCID: https://orcid.org/0000-0001-7289-4507)
Institutions
- Prince Mohammad bin Fahd University (SA)
- Muş Alparslan University (TR)
- Taif University (SA)
- Umm al-Qura University (SA)
- Government College Women University Faisalabad (PK)
- Government College Women University Sialkot
- Assiut University (EG)
- University of Gujrat (PK)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1080/17568919.2025.2550925
- Citations
- 3
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.51
Funders
- Umm Al-Qura University