Association Between Menopause Age and Estradiol-Based Hormone Therapy With Cognitive Performance in Cognitively Normal Women in the CLSA
This study provides Class III evidence that use of E2-based MHTs was associated with higher episodic memory scores (transdermal E2 preparations) or higher prospective memory scores (oral E2 preparations) in postmenopausal women.
Authors
- Kelly J. Murphy (ORCID: https://orcid.org/0000-0002-3827-5814)
- Tanvi A. Puri (ORCID: https://orcid.org/0000-0001-9323-4153)
- Laura L. Gravelsins (ORCID: https://orcid.org/0000-0002-9087-9199)
- Jennifer S. Rabin (ORCID: https://orcid.org/0000-0003-4754-2221)
- Liisa A.M. Galea (ORCID: https://orcid.org/0000-0003-2874-9972)
- Madeline Wood Alexander (ORCID: https://orcid.org/0000-0003-4598-0201)
- Andrew J. McGovern (ORCID: https://orcid.org/0000-0003-0890-5894)
- Paula Duarte Guterman
Institutions
- Sunnybrook Health Science Centre (CA)
- Centre for Addiction and Mental Health (CA)
- University of British Columbia (CA)
- University of Toronto (CA)
- Brock University (CA)
- Toronto Rehabilitation Institute (CA)
- Health Sciences Centre (CA)
- Baycrest Hospital (CA)
- Springboard (Canada) (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Neurology
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1212/wnl.0000000000213995
- Citations
- 9
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.65
Funders
- Government of Canada
- Canadian Institutes of Health Research