Biofilm state Limosilactobacillus reuteri modulates aryl hydrocarbon receptor activity and suppresses experimental necrotizing enterocolitis
Limosilactobacillus reuteri in its biofilm state increases AHR activation and reduces intestinal injury during NEC. This is the first study to look at the role of the AHR signaling pathway in Limosilactobacillus reuteri-mediated protection against NEC. Development of an effective therapy to prevent NEC would reduce the morbidity and mortality of this lethal disease.
Authors
- Samuel G. Volpe
- Joseph Wickham (ORCID: https://orcid.org/0000-0003-3438-0155)
- Lauren Mashburn‐Warren (ORCID: https://orcid.org/0000-0002-3698-4924)
- Michael T. Bailey (ORCID: https://orcid.org/0000-0002-2222-3980)
- Zachary Dumbauld
- Steven D. Goodman (ORCID: https://orcid.org/0000-0002-3315-9320)
- Gail E. Besner (ORCID: https://orcid.org/0000-0002-9280-4836)
- Ameer Al‐Hadidi (ORCID: https://orcid.org/0000-0002-2416-6449)
- Nitin Sajankila
- Mecklin V. Ragan (ORCID: https://orcid.org/0000-0001-5455-7291)
- Belgacem Mihi
- Samantha J. Wala
- Siddharth Narayanan (ORCID: https://orcid.org/0000-0002-5553-3221)
- Yijie Wang (ORCID: https://orcid.org/0000-0001-6959-8619)
- Colton Wayne (ORCID: https://orcid.org/0009-0003-4271-4116)
- Taylor Jacobs
Institutions
- Nationwide Children's Hospital (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1038/s41390-025-04351-z
- Citations
- 2
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- Association for Academic Surgery Foundation
- Ohio State University
- Nationwide Children's Hospital
- National Institutes of Health
- Research Institute, Nationwide Children's Hospital