Long-term immunogenicity and boostability of rabies pre-exposure prophylaxis (PrEP) in immunocompromised adults who received PrEP prior to the start of immunosuppressive therapy: an exploratory study
In 19 patients on immunosuppressive monotherapy who received rabies pre-exposure prophylaxis (PrEP) whilst immunocompetent, all but one showed boostability (antibodies > 0.5 IU/mL) 7 days after post-exposure prophylaxis (PEP) 1-20 years post-PrEP. Tailoring guidelines for specific immunocompromised patient groups is advisable and may improve vaccine coverage and optimize rabies immunoglobulin use.
Authors
- Sanne Terryn (ORCID: https://orcid.org/0000-0002-5524-9984)
- Inne Nauwelaers (ORCID: https://orcid.org/0000-0003-3577-6776)
- Jenny L Schnyder (ORCID: https://orcid.org/0000-0002-2691-8130)
- Kim van Sinderen
- Abraham Goorhuis (ORCID: https://orcid.org/0000-0001-7423-6217)
- Martin P. Grobusch (ORCID: https://orcid.org/0000-0002-0046-1099)
- Cornelis Stijnis (ORCID: https://orcid.org/0000-0002-8955-6288)
- Nita Schipper-Boer
Institutions
- Central Military Hospital (NL)
- Sciensano (Belgium) (BE)
- Amsterdam University Medical Centers (NL)
- Institut Scientifique de Santé Publique (BE)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Travel Medicine
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1093/jtm/taaf085
- Primary Topic
- Rabies epidemiology and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00