Synthesis of Novel Spiro-Isoxazolidine Derivatives of 9α-Hydroxyparthenolide
The 1,3-dipolar cycloaddition reaction was applied to 9α-hydroxyparthenolide, an important sesquiterpene component of Anvillea radiata that was extracted directly from plant material collected in Morocco. Several new spiro-isoxazolidine derivatives were generated on the B-ring of 9α-hydroxyparthenolide (α-methylene-γ-butyrolactone (1)) by 1,3-dipolar cycloaddition of its exocyclic double bond with various nitrones. These compounds were fully characterized by spectroscopic methods.
Authors
- Mohammed Loubidi (ORCID: https://orcid.org/0000-0001-5382-8088)
- Sabine Berteina‐Raboin (ORCID: https://orcid.org/0000-0002-4577-4988)
- Mohamed Zaki (ORCID: https://orcid.org/0000-0002-0297-9510)
Institutions
- Université d'Orléans (FR)
- Centre National de la Recherche Scientifique (FR)
- École Normale Supérieure (BI)
- Institut de Chimie Organique et Analytique (FR)
Publication Details
- Journal
- Molbank
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3390/m2054
- Primary Topic
- Synthesis of heterocyclic compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00