Musculoskeletal Pain Among University Students and Its Correlations with Risk Factors: A Cross-Sectional Study

<b>Background:</b> Several studies have examined the prevalence of musculoskeletal pain (MSP) among university students internationally. We aimed to assess the prevalence, pattern, and potential risk factors for MSP among Majmaah University students in Saudi Arabia. <b>Methods:</b> A cross-sectional questionnaire was administered to students from different faculties at Majmaah University. We collected data via the validated Arabic versions of the Standardized Nordic Musculoskeletal Questionnaire, the International Physical Activity Questionnaire, and the Perceived Stress Scale. Bivariate and multivariate logistic regression analyses were performed to explore associations between MSP and demographic, ergonomic, lifestyle, and psychosocial variables. <b>Results:</b> A total of 257 students (<i>n</i> = 195, 75.9% female; <i>n</i> = 62, 24.1% male) were included in this study. The 12-month prevalence of MSP was 225 (87.5%), with the lower back (<i>n</i> = 119, 46.3%) and neck (<i>n</i> = 113, 44.0%) regions being the most affected. Compared with male students, female students reported a higher MSP prevalence (90.3% vs. 79.0%, <i>p</i> = 0.035). The multivariable model was significant (likelihood-ratio χ² = 26.042, df = 7, <i>p</i> < 0.001), accounted for Nagelkerke R² = 0.182 of variance, and showed good calibration (Hosmer-Lemeshow χ² = 8.505, df = 8, <i>p</i> = 0.386). Perceived stress was the only independent predictor of 12-month MSP (β = 0.084, adjusted OR = 1.087, 95% CI 1.034-1.143, Wald χ² = 10.732, <i>p</i> = 0.001), while sex, smoking, academic workload, and sleep duration were non-significant (all <i>p</i> > 0.127). <b>Conclusions:</b> MSP appears to be prevalent among Majmaah University students, with psychological stress emerging as a key independent risk factor. Preventive strategies should include stress management prioritization and ergonomic and physical activity education to support university student well-being.