CD40L and IL-4 suppress NK cell-mediated antibody-dependent cellular cytotoxicity through the HLA-E:NKG2A axis
These results reveal a novel mechanism of resistance to anti-CD20 therapy in B cell malignancies and demonstrate that the combination of anti-NKG2A with anti-CD20 could improve the treatment of patients with CLL or NHL.
Authors
- Ali Roghanian (ORCID: https://orcid.org/0000-0003-1316-4218)
- Martin C. Taylor (ORCID: https://orcid.org/0000-0003-4147-0693)
- Marco V. Haselager (ORCID: https://orcid.org/0000-0002-1410-7285)
- Benjamin Sale (ORCID: https://orcid.org/0000-0003-3292-1886)
- Andrés F. Vallejo (ORCID: https://orcid.org/0000-0002-4688-0598)
- Kerry L. Cox (ORCID: https://orcid.org/0000-0003-0492-3024)
- Russell B. Foxall (ORCID: https://orcid.org/0000-0001-9821-0708)
- Eric Eldering (ORCID: https://orcid.org/0000-0003-0561-6640)
- Robert J. Oldham (ORCID: https://orcid.org/0000-0002-8007-1145)
- Jamie Lee Roos
- Jack G. Fisher (ORCID: https://orcid.org/0000-0002-5090-7503)
- Margaret Ashton‐Key (ORCID: https://orcid.org/0000-0002-7451-363X)
- Mark Steven Cragg (ORCID: https://orcid.org/0000-0003-2077-089X)
- Francesco Forconi (ORCID: https://orcid.org/0000-0002-2211-1831)
- Matthew D. Blunt (ORCID: https://orcid.org/0000-0003-1099-3985)
- Mel John
- Laura G. Bartlett (ORCID: https://orcid.org/0009-0007-4880-5800)
- Ludmila Horehajova
Institutions
- University Hospital Southampton NHS Foundation Trust (GB)
- Oncode Institute (NL)
- Lymphoma Study Association (FR)
- Institute of Infection and Immunity (CA)
- University of Southampton (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Immunotherapy Advances
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1093/immadv/ltaf029
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Leukaemia UK
- Cancer Research UK
- National Institute for Health and Care Research
- University of Southampton
- Medical Research Council