Genome-Wide Pleiotropy Analysis Identifies Shared and Opposing Pathways Influencing Coronary Artery Disease and Cancer
Our findings highlight shared and opposing genetic loci between CAD and cancer and provide insight into molecular intermediates mediating joint disease risk. Importantly, they indicate potential drug repurposing opportunities for dual CAD and cancer prevention while highlighting possible adverse and divergent effects of existing medications across both conditions.
Authors
- James Yarmolinsky (ORCID: https://orcid.org/0000-0003-4371-0873)
- Evelyn Lau (ORCID: https://orcid.org/0000-0003-3281-8360)
- Ioanna Tzoulaki (ORCID: https://orcid.org/0000-0002-4275-9328)
- Fotios Koskeridis (ORCID: https://orcid.org/0000-0002-1253-7556)
- Dennis Wang (ORCID: https://orcid.org/0000-0003-0068-1005)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Abbas Dehghan (ORCID: https://orcid.org/0000-0001-6403-016X)
Institutions
- Agency for Science, Technology and Research (SG)
- Academy of Athens (GR)
- Biomedical Research Foundation of the Academy of Athens (GR)
- Lung Institute (US)
- Singapore Institute for Clinical Sciences (SG)
- UK Dementia Research Institute (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1161/atvbaha.125.322433
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00