PROS1 released by lung basal cells limits inflammation in epithelial and monocytes during SARS-CoV-2 infection
These findings highlight the crucial role of PROS1 in protecting against severe lung pathology caused by SARS-CoV-2, by reducing epithelial- and monocyte-derived inflammation, promoting pro-repair epithelial phenotypes, and enhancing antigen presentation in myeloid cells.
Authors
- Stefano Alivernini (ORCID: https://orcid.org/0000-0002-7383-4212)
- Thomas D. Otto (ORCID: https://orcid.org/0000-0002-1246-7404)
- Theodoros Simakou (ORCID: https://orcid.org/0000-0002-0839-6383)
- Aziza Elmesmari (ORCID: https://orcid.org/0000-0001-7755-6283)
- Mariola Kurowska‐Stolarska (ORCID: https://orcid.org/0000-0003-2124-7777)
- Domenico Somma (ORCID: https://orcid.org/0000-0003-2486-7250)
- Arvind H. Patel (ORCID: https://orcid.org/0000-0003-4600-2047)
- Jack Frew (ORCID: https://orcid.org/0000-0003-0816-3325)
- Olympia M Hardy (ORCID: https://orcid.org/0009-0007-5145-8571)
- Karen Kerr (ORCID: https://orcid.org/0009-0001-0194-9678)
- Lucy MacDonald (ORCID: https://orcid.org/0000-0001-7727-3873)
- Katy Diallo
- Agnieszka M. Szemiel (ORCID: https://orcid.org/0000-0003-3085-9994)
- Charles McSharry (ORCID: https://orcid.org/0000-0003-4758-9038)
- Marcus Doohan
Institutions
- Agostino Gemelli University Polyclinic (IT)
- MRC University of Glasgow Centre for Virus Research (GB)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Institute of Infection and Immunity (CA)
- University of Glasgow (GB)
Publication Details
- Journal
- Discovery Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/discim/kyaf012
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00