Role of Structural Versus Cellular Remodeling in Atrial Arrhythmogenesis: Insights From Personalized Digital Twins
AF driver locations in atrial fibrotic substrates depend on electrophysiological remodeling; differences between pathology-specific models are explained by differences in wavebreak patterns. Specifically, reentrant drivers tend to dwell in the regions with the highest wavebreak probability.
Authors
- Igor R. Efimov (ORCID: https://orcid.org/0000-0002-1483-5039)
- Roman A. Syunyaev (ORCID: https://orcid.org/0000-0001-9582-0199)
- Vanessa Steckmeister (ORCID: https://orcid.org/0000-0002-9299-000X)
- Ingo Kutschka (ORCID: https://orcid.org/0000-0002-7358-3513)
- Niels Voigt (ORCID: https://orcid.org/0000-0001-8230-2341)
- Anna Gams (ORCID: https://orcid.org/0000-0002-3052-8469)
- Adityo Prakosa (ORCID: https://orcid.org/0000-0002-1590-0322)
- Eric Rytkin (ORCID: https://orcid.org/0000-0003-2511-0655)
- Natalia A. Trayanova (ORCID: https://orcid.org/0000-0002-8661-063X)
- Patrick M. Boyle (ORCID: https://orcid.org/0000-0001-9048-1239)
- Andrey V. Pikunov (ORCID: https://orcid.org/0000-0002-5980-8499)
- Rheeda L. Ali (ORCID: https://orcid.org/0000-0001-5853-8258)
Institutions
- Northwestern University (US)
- University of Nottingham (GB)
- Johns Hopkins University (US)
- George Washington University (US)
- Johns Hopkins Medicine (US)
- Northwestern University (PH)
- German Centre for Cardiovascular Research (DE)
- Bioengineering Center (RU)
- Northwestern Medicine (US)
- Oldham Council (GB)
- Institute of Pharmacology (CZ)
- University of Göttingen (DE)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1161/circep.125.013898
- Citations
- 2
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.78