Growth differentiation factor 11 attenuates sepsis-associated acute kidney injury by reducing inflammation and coagulation via PGC-1α/Nrf2 activation
In summary, these findings indicate that GDF11 is a potential therapeutic approach for SAKI and highlight the crucial role of PGC-1α/Nrf2 signaling in GDF11-mediated renal protection during SAKI.
Authors
- Chenyu Wu (ORCID: https://orcid.org/0000-0002-6450-6268)
- Chaosheng Lu (ORCID: https://orcid.org/0000-0003-2270-0326)
- Chen Zhou (ORCID: https://orcid.org/0000-0001-5684-4462)
- Jingye Pan (ORCID: https://orcid.org/0000-0002-2367-1275)
- Shuang Luo (ORCID: https://orcid.org/0009-0001-1108-1825)
- Yin Wang (ORCID: https://orcid.org/0000-0002-3444-000X)
- Hongwei Wang (ORCID: https://orcid.org/0000-0001-9494-8780)
- Rongrong Zhang (ORCID: https://orcid.org/0009-0007-9427-3729)
- Min Zhu (ORCID: https://orcid.org/0000-0002-5669-9602)
- Yiyang Qin (ORCID: https://orcid.org/0009-0002-6379-0188)
- Keqi Wang (ORCID: https://orcid.org/0000-0003-3175-5089)
- Minmin Wu (ORCID: https://orcid.org/0000-0002-1704-7548)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s11658-025-00762-2
- Citations
- 2
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Natural Science Foundation of Zhejiang Province