Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward
NAcC chemogenetic manipulations alter ethanol reward differently in male and female B6 mice. Together with prior work, we demonstrate that NAcC activity has a sex-specific role during ethanol reward and consumption. Evidence of sex differences in ethanol reward may help future research to uncover the mechanisms underlying the "telescoping effect" and why women have an increased risk for developing an AUD.
Authors
- Angela R. Ozburn (ORCID: https://orcid.org/0000-0002-8387-1156)
- Amy E. Chan (ORCID: https://orcid.org/0000-0002-7362-4936)
- Gillian S. Driscoll (ORCID: https://orcid.org/0000-0003-1905-2620)
- Zaynah Usmani (ORCID: https://orcid.org/0009-0009-7964-9665)
Institutions
- Oregon Health & Science University (US)
- VA Portland Health Care System (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s13293-025-00745-0
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Achievement Rewards for College Scientists Foundation
- National Institute on Alcohol Abuse and Alcoholism