Primary tumor sidedness and negative hyperselection to modulate anti-EGFR-based maintenance strategies in patients with RAS wild-type metastatic colorectal cancer: individual patient data pooled analysis of two randomized clinical trials
Tumor sidedness and hyperselection status significantly influence maintenance strategy efficacy in mCRC. For left-sided, negative hyperselected patients, Panitumumab monotherapy may optimize efficacy while minimizing toxicity. Further investigation into the relative contribution of individual hyperselection parameters in this setting is warranted.
Authors
- Arndt Stahler (ORCID: https://orcid.org/0000-0003-1041-0137)
- Alessandra Raimondi (ORCID: https://orcid.org/0000-0002-8999-2899)
- Armin Jarosch (ORCID: https://orcid.org/0000-0002-6040-394X)
- Sebastian Stintzing (ORCID: https://orcid.org/0000-0002-3297-5801)
- Annika Kurreck (ORCID: https://orcid.org/0000-0002-4352-6788)
- Alexej Ballhausen (ORCID: https://orcid.org/0000-0002-5470-4973)
- Andreas Jay Kind (ORCID: https://orcid.org/0000-0002-8847-5574)
- Michele Prisciandaro (ORCID: https://orcid.org/0000-0001-5596-469X)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Dominik Paul Modest (ORCID: https://orcid.org/0000-0002-6853-0599)
- Annabel Helga Sophie Alig (ORCID: https://orcid.org/0000-0002-3922-3450)
- Federica Morano (ORCID: https://orcid.org/0000-0002-5306-3596)
- Giovanni Randon (ORCID: https://orcid.org/0000-0003-0244-445X)
- David Horst (ORCID: https://orcid.org/0000-0003-4755-5743)
- Chiara Pircher (ORCID: https://orcid.org/0000-0001-8173-824X)
- Filippo Pietrantonio (ORCID: https://orcid.org/0000-0002-8530-8420)
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
- Anna Chiaramonte
- Paola Andena
- Susanna Swoboda
Institutions
- University of Pisa (IT)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Humboldt-Universität zu Berlin (DE)
- Istituto Oncologico Veneto (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1038/s41416-025-03164-5
- Citations
- 3
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.14