The canine T cell receptor repertoire
An individual's TCR repertoire includes stable information, indicative of the individual, breed, and age-related decline. The α and β chain repertoires had distinct properties in the breed-specific signatures, indicating differential influences on their selection, despite their pairing in each T cell. Consistent, age-related changes can be seen in the repertoire, but their impact on immune system needs to be delineated.
Authors
- Richard Haydock
- David Allaway (ORCID: https://orcid.org/0000-0003-4602-8933)
- Matthew Tom Harrison (ORCID: https://orcid.org/0000-0001-7425-452X)
- Anitha D. Jayaprakash (ORCID: https://orcid.org/0000-0002-9466-243X)
- Claire Pink
- Ravi Sachidanandam (ORCID: https://orcid.org/0000-0001-9844-4459)
Institutions
- Oakland University (US)
- New York Medical College (US)
- Leicester City Council (GB)
- Mars (United States) (US)
- Advanced Research Institute (US)
- Leicestershire Partnership NHS Trust (GB)
Publication Details
- Journal
- ImmunoHorizons
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1093/immhor/vlaf040
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00