Pharmacological Investigation of Acute Oral Toxicity of Ethanolic Extract of Crossandra Infundibuliformis Linn Aerial Parts in Albino Rats

The present study is to evaluate the acute toxicity profile of Crosandra infundibuliformis plant extract in albino rats using OECD guidelines. Crossandra infundibuliformis ethanolic extract was administered orally by oral gavage in single dose of 2000mg/kg then observed for 14 days. The animals were observed for clinical observation, changes and carried out haematological studies.The body weight of animals was elevated steadily in vehicle treated groups and extract treated animals within the survey course, the body weights were normal during the 2 weeks of study, Behavioural monitoring of the extract treated animals demonstrated raised respiration rate and somatomotor activity for first hours. Subtle trembling was also detected in the extract treated rats in1st day. Sometimes itching was noticed in extract treated groups in first days of this research, Other than the abovementioned changes, Administration of Crossandra infundibuliformis extract did not induce behavioural changes at any time point in treated rats compared to the control group,all the haematological values in all treated groups were remained within the physiological range after the experimental period. Bases on these results, the ethanolic extract of Crossandra infundibuliformis did not cause any toxicological effect. Theseresult provides basic toxicological profile.