Síntesis Eficiente de δ-Decalactona Enantioméricamente Pura: un Enfoque Ecológico a Partir de Quirones Naturales

An innovative approach presents for the synthesis of enantiomerically pure δ-decalactone, using the lactone 7,3-LXF as a precursor. Highly selective reactions such as furan opening, diasteroselective allylation, and Corey-Winter olefination led to 6, which upon hydrogenation gives d-lactone. The overall yield was 51%. Tetrahydro-6-(1-penten-1-yl)-2H-pyran-2one was also obtained, opening new possibilities in lactone chemistry.