Bone marrow-derived extracellular vesicles from multiple myeloma patients promote adaptive immune dysfunction via HLA-G, PD-1, and PD-L1
HLA-G<sup>+</sup>, PD-1<sup>+</sup>, and PD-L1<sup>+</sup> EVs contribute to immune dysfunction in MM and represent promising targets to restore anti-tumor immunity.
Authors
- Francesco Lai
- Roberto Gramignoli (ORCID: https://orcid.org/0000-0003-3362-4170)
- Michele Cea (ORCID: https://orcid.org/0000-0002-1530-6729)
- Fabio Morandi (ORCID: https://orcid.org/0000-0002-2849-7595)
- Danilo Marimpietri (ORCID: https://orcid.org/0000-0001-6360-1661)
- Debora Soncini (ORCID: https://orcid.org/0000-0001-5156-498X)
- Francesco Ladisa
- Irma Airoldi (ORCID: https://orcid.org/0000-0002-4352-8396)
Institutions
- Istituto Giannina Gaslini (IT)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1640168
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Sanofi
- International Myeloma Society
- Paula and Rodger Riney Foundation
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro