Multi-omics approach to personalised treatment: insights into thrombus-derived exosome regulation in cardiomyocyte ferritinophagy
This study is the first to reveal the critical role of the "FENDRR-m6A-NCOA4" regulatory axis as a critical mediator of ferritinophagy in T1MI. It also suggests that immune cells may participate in the immune-inflammatory response associated with myocardial injury via ferritinophagy. Our research provides multi-omics evidence of the interaction between iron homeostasis, immunity, and inflammation in T1MI, offering potential therapeutic strategies for targeting ferritinophagy and related RNA modification pathways.
Authors
- Lin Ai (ORCID: https://orcid.org/0000-0002-8688-7778)
- Qiang Wu (ORCID: https://orcid.org/0000-0002-9169-3791)
- Jing Huang (ORCID: https://orcid.org/0000-0001-5612-4174)
- Yu Zhou (ORCID: https://orcid.org/0009-0002-2826-5150)
- Youfu He (ORCID: https://orcid.org/0000-0003-4926-1706)
- Xiangshu Long (ORCID: https://orcid.org/0000-0001-7156-7109)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Guiyang University (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1607355
- Citations
- 6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.84