CDKN2A deletion is associated with immune desertification in diffuse pleural mesothelioma
These data demonstrated that CDKN2Adel deeply affects the spatial organization of immune microenvironment by depleting immune-signaling and reducing or preventing immune infiltration, supporting the potential implementation of this alteration as ICIs predictive biomarker in DPM.
Authors
- Gloria Manzotti (ORCID: https://orcid.org/0000-0002-0639-3605)
- Veronica Manicardi (ORCID: https://orcid.org/0000-0003-2490-7283)
- Alessia Ciarrocchi (ORCID: https://orcid.org/0000-0002-5541-2075)
- Benedetta Donati (ORCID: https://orcid.org/0000-0002-9163-8194)
- Nicola Facciolongo
- Francesca Reggiani (ORCID: https://orcid.org/0000-0002-4090-8908)
- Pierluigi Di Chiaro (ORCID: https://orcid.org/0000-0002-9179-1922)
- Federica Torricelli (ORCID: https://orcid.org/0000-0003-1954-5695)
- Filippo Lococo (ORCID: https://orcid.org/0000-0002-9383-5554)
- Simonetta Piana (ORCID: https://orcid.org/0000-0003-4875-6977)
- Mila Gugnoni (ORCID: https://orcid.org/0000-0003-4630-3958)
- Riccardo Valli (ORCID: https://orcid.org/0000-0001-7289-8479)
- Roberto Piro (ORCID: https://orcid.org/0000-0003-1046-4848)
- Cristian Ascione (ORCID: https://orcid.org/0009-0007-3297-0262)
- Massimiliano Paci (ORCID: https://orcid.org/0000-0001-7400-1792)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s13046-025-03522-4
- Citations
- 4
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- European Commission
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro