Proteomics reveals periodontitis-driven oxidative stress and lipid metabolism disruption in NAFLD
Periodontitis accelerates NAFLD progression through oxidative stress and lipid metabolism dysfunction. ACOX1, DBT, ACAA2, and HADHA may serve as therapeutic targets. These findings highlight the importance of oral health in systemic metabolic disorders and suggest new intervention strategies.
Authors
- Hongjiao Li
- Zhengyu Guan
- S. Qi (ORCID: https://orcid.org/0009-0000-7983-0020)
- Xiaomeng Liu (ORCID: https://orcid.org/0000-0002-1212-2772)
- Yixuan Jiang (ORCID: https://orcid.org/0000-0002-9833-7984)
- Boyuan Sun
Institutions
- XinHua Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3389/fendo.2025.1600015
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China