NK cell-related genes-driven novel molecular subtyping and prognostic signatures for Wilms tumor: uncovering the therapeutic potential of TGX-221 and biomarker role of HS2ST1
Molecular subtyping and prognostic signatures based on NKGs enable the precise identification of high-risk WT patients. Moreover, TGX-221 represents a promising novel therapeutic candidate, while HS2ST1 serves as a potential prognostic biomarker. These findings collectively provide tools for risk stratification and targeted therapy, advancing precision oncology for WT.
Authors
- Hong Peng (ORCID: https://orcid.org/0000-0002-3028-8872)
- Kemi Cui (ORCID: https://orcid.org/0000-0003-4064-468X)
- Qinlin Shi (ORCID: https://orcid.org/0000-0001-6619-1135)
- Zhiyuan Hu (ORCID: https://orcid.org/0000-0003-2212-0268)
- Xiao‐Mao Tian (ORCID: https://orcid.org/0000-0002-9900-7450)
- Zhiqiang Gao (ORCID: https://orcid.org/0000-0002-6160-1147)
- Jie Lin (ORCID: https://orcid.org/0000-0003-3784-8120)
- Tao Lin (ORCID: https://orcid.org/0000-0003-1849-1656)
- Guanghui Wei
Institutions
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3389/fonc.2025.1593011
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00