Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface
We discovered distinct as well as shared molecular pathways associated with RPL pathogenesis before and after the start of placental circulation and identified novel biomarkers for these pathways which have outstanding discriminative properties. Our results may facilitate a better understanding of the molecular pathways of RPL. However, larger clinical studies are needed to investigate whether the identified biomarkers also have predictive power for RPL before pregnancies fail and to test drugs for the modulation of the identified disease pathways and the prevention of RPL. Our findings highlight the importance of the maternal immune system in maintaining successful pregnancy and suggest that targeting immune pathways may offer novel therapeutic approaches for RPL.
Authors
- Eszter Tóth (ORCID: https://orcid.org/0000-0001-7149-1482)
- Nándor Gábor Than (ORCID: https://orcid.org/0000-0001-9385-7019)
- Nándor Ács (ORCID: https://orcid.org/0000-0002-1919-1869)
- Máté Posta
- Claudia Escher
- Sándor Nagy (ORCID: https://orcid.org/0000-0002-7054-8333)
- Dániel Györffy (ORCID: https://orcid.org/0009-0006-3301-5542)
- Petronella Hupuczi
- Olga Török
- Orsolya Oravecz (ORCID: https://orcid.org/0000-0002-7342-183X)
- Oliver Rinner
- L Veress
- Offer Erez (ORCID: https://orcid.org/0000-0002-2213-8129)
- András Szilágyi (ORCID: https://orcid.org/0000-0002-1773-6861)
- Andrea Balogh (ORCID: https://orcid.org/0000-0003-0322-1522)
- Zoltán Papp (ORCID: https://orcid.org/0000-0002-7532-9703)
- Magdalena Bober
- E Farkas
Institutions
- Semmelweis University (HU)
- Eötvös Loránd University (HU)
- Ben-Gurion University of the Negev (IL)
- University of Debrecen (HU)
- Pázmány Péter Catholic University (HU)
- Maternity Foundation (DK)
- Biognosys (Switzerland) (CH)
- HUN-REN Research Centre for Natural Sciences (HU)
- Széchenyi István University (HU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1621168
- Citations
- 1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- European Commission
- Hungarian Scientific Research Fund
- Magyar Tudományos Akadémia
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap