ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway
Our findings suggest that the loss of ATP/P2X7 signaling in CD4<sup>+</sup>T cells may inhibit the pSTAT3, IL-21 pathway, leading to reduced differentiation of Th17 cells and ultimately mitigating IR injury. This provides novel insights into the role of ATP/P2X7-mediated signaling in T cell inflammation during ischemic stroke.
Authors
- Paiyu Liu
- Bing Ni (ORCID: https://orcid.org/0000-0002-4297-5346)
- Zhiqiang Song (ORCID: https://orcid.org/0000-0003-3934-4938)
- Mengjie Zhang (ORCID: https://orcid.org/0000-0002-2656-3341)
- Jun Yin (ORCID: https://orcid.org/0000-0002-7541-1088)
- Wenying Liu (ORCID: https://orcid.org/0009-0002-6251-5475)
- Denghui Li (ORCID: https://orcid.org/0000-0003-1610-0148)
- Peng Wang (ORCID: https://orcid.org/0000-0001-7601-8483)
- Yanmeng Peng
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1558307
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- National Natural Science Foundation of China