TRAP1 expression elicits pro-tumoral functions in macrophages associated to malignant peripheral nerve sheath tumor cells
Our data provide evidence of a molecular crosstalk between MPNST cellular components, in which soluble factors released by cancer cells drive phenotypic changes in macrophages that in turn enhance pro-tumoral biological routines in both MPNST and endothelial cells. TRAP1-dependent metabolic rewiring in macrophages is mandatory for sustaining this interplay, as a TRAP1-succinate-HIF-1α signaling axis orchestrates their acquisition of tumor-promoting features.
Authors
- Camilla Bean (ORCID: https://orcid.org/0000-0001-6491-7211)
- Valentina Zappulli (ORCID: https://orcid.org/0000-0001-6203-0190)
- Francesca Scantamburlo
- Marco Fantuz (ORCID: https://orcid.org/0000-0001-7758-3660)
- Mariacristina Toffanin
- Ionica Masgras (ORCID: https://orcid.org/0000-0002-9768-460X)
- Alessia Rubini (ORCID: https://orcid.org/0000-0002-2603-0801)
- Susanna Tomasoni (ORCID: https://orcid.org/0000-0002-7212-2512)
- Ranieri Verin (ORCID: https://orcid.org/0000-0001-9366-5682)
- Andrea Rasola (ORCID: https://orcid.org/0000-0003-4522-3008)
- Francesco Ciscato (ORCID: https://orcid.org/0000-0003-2298-1439)
- Maria Egle Castorina
- Paolo Finotti
Institutions
- University of Pisa (IT)
- University of Udine (IT)
- University of Padua (IT)
- Veneto Institute of Molecular Medicine (IT)
- Neuroscience Institute (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s13046-025-03525-1
- Citations
- 2
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- Fondazione Cassa di Risparmio di Padova e Rovigo
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Padova
- Associazione Italiana per la Ricerca sul Cancro
- Ministero dell'Università e della Ricerca