Elevated total cholesterol in healthy adults mediates the association between impaired thyroid hormone sensitivity and hyperuricemia

This study is the first to uncover a new relevance by which impaired thyroid hormone sensitivity mediates hyperuricemia through total cholesterol. This finding provides fresh epidemiological evidence for the interplay between thyroid dysfunction and hyperuricemia and suggests that monitoring thyroid hormone sensitivity indices in high-risk populations for hyperuricemia might be conducive in early risk stratification. Moreover, lipid-lowering treatment in subclinical thyroid dysfunction patients may simultaneously enhance uric acid metabolism, offering creative insights for the precise prevention and management of hyperuricemia.