Sex Hormone Profiles in Patients With Torsades de Pointes Ventricular Tachycardia
Different sex hormone profiles, primarily low testosterone in male patients and high 17β-estradiol in female patients, are associated with TdP occurrence and outcome in men and women. These endocrine milieus act, at least in part, via direct and reversible effects on cardiac electrophysiology, thereby supporting the antiarrhythmic potential of sex-specific hormonal-modulating therapies.
Authors
- Decoroso Verrengia (ORCID: https://orcid.org/0000-0002-8227-6339)
- Matteo Capecchi (ORCID: https://orcid.org/0000-0003-1541-0689)
- Maria Grazia Castagna (ORCID: https://orcid.org/0000-0002-2457-1751)
- Franco Laghi‐Pasini (ORCID: https://orcid.org/0000-0003-0146-4416)
- Mohamed Boutjdir (ORCID: https://orcid.org/0000-0002-6068-223X)
- Viola Salvini
- Jean‐Baptiste Reisqs (ORCID: https://orcid.org/0000-0001-9881-6670)
- Riccardo Accioli (ORCID: https://orcid.org/0000-0003-1983-4040)
- Pier Leopoldo Capecchi (ORCID: https://orcid.org/0000-0001-7021-7764)
- Vamsi Krishna Murthy Ginjupalli (ORCID: https://orcid.org/0000-0002-5022-1683)
- Pietro Enea Lazzerini (ORCID: https://orcid.org/0000-0001-6721-1214)
- Antonio Abbate (ORCID: https://orcid.org/0000-0002-1930-785X)
- Alessandra Cartocci (ORCID: https://orcid.org/0000-0002-1818-6275)
- Antônio Alberto D'Errico (ORCID: https://orcid.org/0000-0002-3783-2535)
- Yongxia Qu
- Fabio Salvadori (ORCID: https://orcid.org/0000-0003-0964-4075)
- Iacopo Bertolozzi
- Anna Cantore (ORCID: https://orcid.org/0009-0004-6890-3502)
- Tommaso Marzotti (ORCID: https://orcid.org/0009-0007-8944-2735)
- Silvia Cantara (ORCID: https://orcid.org/0000-0002-5741-295X)
- Michele Voglino
- Maurizio Acampa (ORCID: https://orcid.org/0000-0003-4149-1785)
- Sciaila Bernardini (ORCID: https://orcid.org/0009-0009-7848-6171)
- Stefania Bisogno
Institutions
- University of Siena (IT)
- Nuovo Ospedale San Giovanni di Dio (IT)
- University of Virginia (US)
Publication Details
- Journal
- JACC. Clinical electrophysiology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1016/j.jacep.2025.07.009
- Citations
- 3
- Primary Topic
- Cardiac Arrhythmias and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- European Commission
- Regione Toscana
- National Heart, Lung, and Blood Institute