Formulation and Characterization of Transdermal Patches of Baclofen for Pain Management

Bacofen transdermal patches made using the solvent casting method and composed of the plasticizer dibutylpthalate and the polymers ethyl cellulose and Eudragit RL100 are very stable. The patches had an average weight of 161–167 mg, with a surface area of 1.5 cm2. The patches' thickness varied between 0.267 and 0.354 mm, with the exact value depending on the polymer ratio. In the folding endurance test, the patches withstood 47–83 folds in the same spot. The medication concentrations in all of the formulations ranged from 97-80.9 percent. The medication was released in a range of formulations, from 88.3% to 60.7%. The regression coefficients of the mathematical model's graphical depiction show that the Korsemeyer-Peppas model can describe the release of etodolac from the patches. The phrase describes how the medicine is released from the patches mainly by diffusion control, from the patch's polymeric matrix.