Spatial tumour characteristics as an indirect marker of metabolic dysregulation: evaluation for non-invasive IDH-genotyping of glioma using hybrid [18 F]FET-PET/MRI
Spatial mapping of treatment-naïve glioma identified a non-invasive biomarker, which is linked to metabolic dysfunction and enabled robust IDH-genotype classification from standard MRI, suggesting a central role for radiogenomic assessment in adult-type diffuse gliomas prior to surgery.
Authors
- Helena Radbruch (ORCID: https://orcid.org/0000-0001-6941-3397)
- Jenny Meinhardt (ORCID: https://orcid.org/0000-0003-0366-2416)
- Marcus R. Makowski (ORCID: https://orcid.org/0000-0001-8778-647X)
- Johannes Lohmeier (ORCID: https://orcid.org/0000-0002-8927-2453)
- Winfried Brenner (ORCID: https://orcid.org/0000-0003-2478-6004)
- Anna Tietze (ORCID: https://orcid.org/0000-0002-2601-9055)
- Mauricio Reyes
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
- TUM Klinikum (DE)
- Humboldt-Universität zu Berlin (DE)
- Technical University of Munich (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1007/s00259-025-07520-8
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Charité – Universitätsmedizin Berlin