Bridging physics and practice: evaluating sensitivity, septal penetration, and detector dead time in terbium-161 gamma-camera imaging
While high-quality <sup>161</sup>Tb SPECT imaging is feasible, careful consideration is essential; the wide range of photons emitted will produce a higher wide-spectrum count rate as compared to <sup>177</sup>Lu. The use of low-energy collimators increases penetration and scatter, impairing quantitative accuracy and elevating the wide-spectrum count rate, which may intensify dead-time effects. At therapeutic activity levels (e.g., 7.4 GBq), dead time should be closely monitored to ensure reliable quantification.
Authors
- Nicholas Philip van der Meulen (ORCID: https://orcid.org/0000-0001-6077-5594)
- Frida Westerbergh (ORCID: https://orcid.org/0009-0006-3704-7357)
- Damian Wild (ORCID: https://orcid.org/0000-0002-8135-5350)
- Philipp Ritt
- Roger Schibli (ORCID: https://orcid.org/0000-0002-1537-3833)
- Peter Bernhardt (ORCID: https://orcid.org/0000-0003-1984-4353)
- Lisa McDougall
- Julia Fricke (ORCID: https://orcid.org/0009-0008-0030-9565)
- Cristina Müller (ORCID: https://orcid.org/0000-0001-9357-9688)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Sahlgrenska University Hospital (SE)
- Paul Scherrer Institute (CH)
- University Hospital of Basel (CH)
- ETH Zurich (CH)
- Isotopen Technologien München (Germany) (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s40658-025-00792-x
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Science Foundation
- Universität Basel
- Kungl. Vetenskaps- och Vitterhets-Samhället i Göteborg
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Cancerfonden
- Vetenskapsrådet
- Göteborgs Universitet