Clinicopathological and genomic analysis of SWI/SNF chromatin remodeling abnormalities with a focus on SMARCA4 in cancer of unknown primary
This study demonstrated SWI/SNF chromatin remodeling abnormalities in CUP and the association between SMARCA4 deficiency and U-CUP. It suggests a potential strategy for selecting an ICI regimen for CUP, particularly U-CUP, with SMARCA4 deficiency.
Authors
- Hiroyasu Oda (ORCID: https://orcid.org/0000-0002-1009-3058)
- Hiroki Oka
- Toshiro Mizuno (ORCID: https://orcid.org/0000-0002-3922-8251)
- Kanako Saito (ORCID: https://orcid.org/0000-0001-7420-563X)
- Yasutaka Tono (ORCID: https://orcid.org/0000-0002-9714-0629)
- Yoshiki Yamashita (ORCID: https://orcid.org/0000-0003-1988-4304)
- Koshi Sukeno
- Akira Tsunoda
- Mariko Okayama
- Satoshi Tamaru (ORCID: https://orcid.org/0000-0002-2959-6077)
- Masayasu Taniguchi (ORCID: https://orcid.org/0000-0003-3422-1904)
- Makoto Ikejiri
- Masaki Tanabe (ORCID: https://orcid.org/0009-0009-9626-6332)
- Hiroshi Imai (ORCID: https://orcid.org/0000-0003-3702-2708)
- Masatoshi Watanabe
Institutions
- Mie University (JP)
- Mie University Hospital (JP)
- Ise Red Cross Hospital (JP)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1007/s00432-025-06293-9
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00