Circular DNA from V(D)J Recombination Promotes Poor Leukemia Outcomes

Major Finding: V(D)J recombination–derived excised DNA circles replicate and are associated with BCP-ALL relapse.Concept: Excised signal circle (ESC) persistence in relapsed BCP-ALL promotes ESC–RAG complex formation and oncogenic mutations.Impact: ESCs resulting from V(D)J recombination are correlated with poor prognosis in leukemia.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-078
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
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article

Circular DNA from V(D)J Recombination Promotes Poor Leukemia Outcomes

Cancer Discovery
Cancer Genomics and Diagnostics
article

Circular DNA from V(D)J Recombination Promotes Poor Leukemia Outcomes

article en

Abstract

Major Finding: V(D)J recombination–derived excised DNA circles replicate and are associated with BCP-ALL relapse.Concept: Excised signal circle (ESC) persistence in relapsed BCP-ALL promotes ESC–RAG complex formation and oncogenic mutations.Impact: ESCs resulting from V(D)J recombination are correlated with poor prognosis in leukemia.

Cancer Discovery
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Openalex Percentile: Top 72%
Cancer Genomics and Diagnostics
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Circular DNA from V(D)J Recombination Promotes Poor Leukemia Outcomes · Cancer Discovery (2025) | TGRS Research Map | TGRS