Genetic evidence for causal links between type 1 diabetes and autoimmune liver diseases
This study provides genetic evidence for a causal effect of T1D on AIH and a likely bidirectional relationship between T1D and PBC. These findings refine our understanding of their comorbidity, suggesting the need for heightened clinical surveillance and warranting further mechanistic investigation to elucidate the biological pathways.
Authors
- Yu Sun (ORCID: https://orcid.org/0000-0003-0863-2769)
- Cuiyue Liang (ORCID: https://orcid.org/0000-0001-7136-5531)
- Yong-Nian Yang
- Xiaocheng Li (ORCID: https://orcid.org/0009-0005-9269-3987)
- Jie Yuan (ORCID: https://orcid.org/0009-0008-5209-3874)
Institutions
- Hunan University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of University of South China (CN)
- Chongqing Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1186/s13098-025-01928-w
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hunan Province