Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling
These findings underscore the therapeutic potential of vinburnine, particularly when used in combination with immune checkpoint inhibitors, as a promising strategy for melanoma treatment.
Authors
- Cong Peng (ORCID: https://orcid.org/0000-0001-7104-5490)
- Susi Zhu
- Siyu Xiong (ORCID: https://orcid.org/0000-0002-5125-3644)
- Zhe Zhou (ORCID: https://orcid.org/0000-0002-0219-6882)
- Waner Liu
- Xu Zhang (ORCID: https://orcid.org/0000-0002-8007-2762)
- Xiang Chen (ORCID: https://orcid.org/0009-0004-4005-9549)
Institutions
- Central South University (CN)
- SKiN Health (CA)
- Hunan Cancer Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1186/s13046-025-03521-5
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Central South University
- Natural Science Foundation of Hunan Province
- Higher Education Discipline Innovation Project
- Xiangya Hospital, Central South University
- Project 211