Integration of genome and transcriptome reveals core genes and allele-specific expression genetic variants associated with immune differentiation of taurine ancestry dairy cattle from indicine ancestry cattle
This study uses high-throughput omics data to provide new insights into the digitalization of immunity, defined as quantifying immune- and disease-related pathway activity through gene expression levels. Our study also provides candidate markers for future functional validation and genomic selection strategies aimed at enhancing immunity in Holstein cattle.
Authors
- Ying Yu (ORCID: https://orcid.org/0000-0002-4524-0791)
- Quanzhen Chen (ORCID: https://orcid.org/0000-0002-7481-9997)
- Xiaoyang Zhu (ORCID: https://orcid.org/0000-0002-7491-7124)
- Kaixing Qu (ORCID: https://orcid.org/0000-0002-7295-7309)
- Yongjie Tang (ORCID: https://orcid.org/0000-0002-3298-9023)
- Qingyao Zhao (ORCID: https://orcid.org/0000-0002-1037-3631)
- Huaming Mao (ORCID: https://orcid.org/0000-0001-8582-2481)
- Zhi Li (ORCID: https://orcid.org/0000-0002-4255-4170)
- Feng Xiao (ORCID: https://orcid.org/0000-0003-3289-3459)
- Siqian Chen (ORCID: https://orcid.org/0009-0004-4737-7443)
Institutions
- Yunnan Agricultural University (CN)
- Beijing University of Technology (CN)
- Chuxiong Normal University (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1186/s12864-025-11936-9
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Earmarked Fund for Modern Agro-industry Technology Research System