Evaluation of a long-term antimicrobial dental adhesive via in vitro biodegradation and in vivo rodent secondary caries models
This comprehensive in vitro and in vivo antimicrobial/antidegradative analysis of a new dental biomaterial, accurately modeling the chemical and biological environment these materials must perform in, provided comprehensive understanding of potential material performance that strongly supports continued development and clinical evaluation. The clinical relevance of the in vitro model used in this study was validated by the in vivo animal model and could be used to assess new dental biomaterials.
Authors
- Sunil V. Rao (ORCID: https://orcid.org/0000-0003-2914-0894)
- Cameron A. Stewart
- Yoav Finer (ORCID: https://orcid.org/0000-0002-1707-2698)
- Zach Gouveia (ORCID: https://orcid.org/0000-0001-9702-3935)
- Andreas Mandelis (ORCID: https://orcid.org/0000-0003-0625-8611)
- Dua Abuquteish (ORCID: https://orcid.org/0000-0001-7269-7853)
- Kimberly Ngai
Institutions
- Hashemite University (JO)
- University of Toronto (CA)
Publication Details
- Journal
- Dental Materials
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1016/j.dental.2025.08.017
- Citations
- 4
- Primary Topic
- Dental materials and restorations
- Type
- article
- Field-Weighted Citation Impact
- 6.70
Funders
- National Institutes of Health
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Ontario Ministry of Research and Innovation