Unintended Consequences: A Review of Pharmacologically Induced Priapism

Background: Tamsulosin in a widely used drug in urology practice in treating lower urinary tract symptoms of benign prostatic hyperplasia, distal ureteral stones, and ureteral stent-related symptoms. Ischemic priapism is a rare but serious adverse effect of tamsulosin. We report two cases of tamsulosin-induced priapism and reviewed available literature citing priapism as a complication of tamsulosin. Aim: To report the presentation and management of a case of Tamsulosin-Induced-Priapism. Case Presentation: Our patients developed priapism after taking tamsulosin for lower urinary tract symptoms, or in the emergency department as medical expulsive therapy for distal ureteral stone. They treated with corporal aspiration and phenylephrine injection and one of them needed surgical intervention. At 6 weeks follow-up visit, all the patient has maintained his potency. Conclusion: Tamsulosin is a useful medication for the management of symptoms related to BPH and distal ureteric calculi. However, its use may be associated on rare occasions by priapism hence Health-care professionals should be aware in order to advice all patients taking such medications about this rare but serious adverse effect and to seek help on time.