Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization

one point three one percent of dementia prevalence globally could be explained by ischemic stroke and hemorrhagic stroke.Quantifying the proportion of dementia caused by these two conditions has helped us to gain a comprehensive understanding of the causes of dementia.Through two-sample MR study and two-step MR analysis, modifiable risk factors and cerebrospinal fluid mediators associated with vascular dementia were identified, elucidating intervention methods for preventing or delaying the typical characteristics of dementia. This is crucial for future efforts in disease prevention and treatment.